Integrins are heterodimeric integral membrane proteins that play key roles in regulating cell-cell and cell-extracellular matrix interactions, which together contribute to tissue formation and initiate signaling pathways that control cell movement, differentiation, growth, and survival. Twenty-four Integrin alpha/beta heterodimers have been identified. These heterodimeric proteins play important roles in cancer, fibrosis, and thrombotic and inflammatory diseases and therefore, have become a key subject of interest for pharmaceutical companies.
R&D Systems is the only company that develops, tests, and sells active Integrin heterodimers including popular pharmaceutical targets such as Integrin alpha 4 beta 7, Integrin alpha 2b beta 3, Integrin alpha V beta 1, Integrin alpha V beta 3, Integrin alpha V beta 5, and Integrin alpha V beta 6. Additionally, we offer a broad range of antibodies against Integrin single chains and heterodimers, as well as a number of small molecules and peptides that act as Integrin inhibitors or antagonists.
Complete listing of Integrin-related Products Available from R&D Systems
Assessment of the Bioactivity and Purity of a Subset of Integrin Heterodimers from R&D Systems
| Integrin α2bβ3 | |
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Recombinant Integrin α2bβ3 Binds Fibronectin. Recombinant Human Integrin α2bβ3 (Catalog # 7148-A2) was coated onto microplate wells at 2 µg/mL and the indicated concentrations of Human Fibronectin (Catalog # 1918-FN) were added. Fibronectin bound to Integrin α2bβ3 in a dose-dependent manner with an apparent KD < 1 nM. |
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SDS-PAGE Analysis of Recombinant Human Integrin α2bβ3 under Reducing Conditions. To assess purity, Recombinant Human Integrin α2bβ3 (Catalog # 7148-A2; 1 µg/lane) was resolved by 4–20% SDS-PAGE under reducing conditions and visualized by silver staining. |
| Integrin αVβ3 | |
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Recombinant Integrin αVβ3 Binds Vitronectin. Recombinant Human Vitronectin (Catalog # 2308-VN) was coated onto microplate wells at 1 µg/mL and increasing concentrations of Recombinant Human Integrin αVβ3 (Catalog # 3050-AV) were added. Integrin αVβ3 bound to Vitronectin in a dose-dependent manner with an apparent KD < 10 nM. |
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SDS-PAGE Analysis of Recombinant Human Integrin αVβ3 under Reducing Conditions. To assess purity, Recombinant Human Integrin αVβ3 (Catalog # 3050-AV; 1 µg/lane) was resolved by 4–20% SDS-PAGE under reducing conditions and visualized by silver staining. |
| Integrin αVβ6 | |
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Recombinant Integrin αVβ6 Binds LAP TGF-β1. Recombinant Human Integrin αVβ6 (Catalog # 3817-AV) was coated onto microplate wells at 2 µg/mL and increasing concentrations of Recombinant Human LAP TGF-β1 (Catalog # 246-LP) were added. LAP TGF-b1 bound to Integrin aVb6 in a dose-dependent manner with an apparent KD <0.1 nM. |
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SDS-PAGE Analysis of Recombinant Human Integrin αVβ6 under Reducing Conditions. To assess purity, Recombinant Human Integrin αVβ6 (Catalog # 3817-AV; 1 µg/lane) was resolved by 4–20% SDS-PAGE under reducing conditions and visualized by silver staining. |
| Integrin α4β7 | |
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Recombinant Integrin α4β7 Supports the Adhesion of VCAM-1-transfected Cells. Cultured Chinese hamster ovary (CHO) cells transfected with VCAM-1 were added to plates coated with increasing concentrations of Recombinant Human Integrin α4β7 (Catalog # 5397-A3). The cells adhered to immobilized Recombinant Human Integrin α4β7 in a concentration-dependent manner. |
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SDS-PAGE Analysis of Recombinant Human Integrin α4β7 under Reducing Conditions. To assess purity, Recombinant Human Integrin α4β7 (Catalog # 5397-A3; 1 µg/lane) was resolved by 4–20% SDS-PAGE under reducing conditions and visualized by silver staining. |
| Integrin αVβ5 | |
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Recombinant Integrin αVβ5 Binds Vitronectin. Recombinant Human Vitronectin (Catalog # 2308-VN) was coated onto microplate wells at 1 µg/mL and increasing concentrations of Recombinant Human Integrin αVβ5 (Catalog # 2528-AV) were added. Integrin αVβ5 bound to Vitronectin in a dose-dependent manner with an apparent KD < 0.5 nM. |
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SDS-PAGE Analysis of Recombinant Human Integrin αVβ5 under Reducing Conditions. To assess purity, Recombinant Human Integrin αVβ5 (Catalog # 2528-AV; 1 µg/lane) was resolved by 4–20% SDS-PAGE under reducing conditions and visualized by silver staining. |
| Integrin αVβ1 | |
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Recombinant Integrin αVβ1 Binds Fibronectin. Recombinant Human Integrin αVβ1 (Catalog # 6579-AV) was coated onto microplate wells at 5 µg/mL and increasing concentrations of Human Fibronectin (Catalog # 1918- FN) were added. Fibronectin bound to Integrin αVβ1 in a dose-dependent manner with an apparent KD < 0.1 nM. |
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SDS-PAGE Analysis of Recombinant Human Integrin αVβ1 under Reducing Conditions. To assess purity, Recombinant Human Integrin αVβ1 (Catalog # 6579-AV; 1 µg/lane) was resolved by 4-20% SDS-PAGE under reducing conditions and visualized by silver staining. |